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Chris Lau, PhD

Education
PH.D., 06/1979 - GENETICS, MD ANDERSON CANCER CENTER-UTHEALTH
M.S., 06/1976 - CELL BIOLOGY, MD ANDERSON CANCER CENTER-UTHEALTH
B.A., 06/1973 - CHEMISTRY, HARPUR COLLEGE-SUNY
Websites
  • Lau Lab
  • Profile at UCSF Cancer Center
  • Cell & Bioscience Journal
Publications
  1. Kido T, Lau YC. The human testis-specific protein Y-linked (TSPY) is a male-specific cancer-testis antigen capable of eliciting significant immune responses and elimination of positive tumor cells in hepatocellular carcinoma. Cell & bioscience 2025. PMID: 40563082


  2. Kido, T, Kong H, Lau Y-FC. The X-Linked Tumor Suppressor TSPX Regulates Genes Involved in the EGFR Signaling Pathway and Cell Viability to Suppress Lung Adenocarcinoma The X-Linked Tumor Suppressor TSPX Regulates Genes Involved in the EGFR Signaling Pathway and Cell Viability to Suppress Lung Adenocarcinoma 2025. PMID:


  3. Kido T, Lau YC. Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model. Oncogenesis 2023. PMID: 36746917


  4. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Doerr HG, Woelfle J, Heidemann PH, Lau YC, Strowitzki T. Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§. Systems biology in reproductive medicine 2022. PMID: 35481403


  5. Lau YC. The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience. Abdominal radiology (New York) 2021. PMID: 34906230


  6. Lau YC. Y chromosome in health and diseases. 2020. PMID: 32817785


  7. Kido T, Tabatabai ZL, Chen X, Lau YC. Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. 2020. PMID: 32473614


  8. Lau YC, Li Y, Kido T. Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis. 2018. PMID: 29974883


  9. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T. Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY. 2019. PMID: 30753444


  10. Kido T, Lau YC. The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression. 2019. PMID: 30867900


  11. Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. 2019. PMID: 30863497


  12. Kido T, Sun Z, Lau YC. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Scientific Reports 2017. PMID: 28646221


  13. Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. 2017. PMID: 28169398


  14. Kido T, Lau YC. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. 2016. PMID: 27771326


  15. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. 2015. PMID: 26036629


  16. Kido T, Lau YF. Roles of the Y chromosome genes in human cancers. 2015. PMID: 25814157


  17. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. 2014. PMID: 25267720


  18. Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. 2014. PMID: 25088423


  19. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. 2014. PMID: 25017435


  20. Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochemical and biophysical research communications 2014. PMID: 24583132


  21. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. 2014. PMID: 24528896


  22. Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. 2013. PMID: 23975793


  23. Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. 2012. PMID: 22144232


  24. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PloS one 2011. PMID: 21829568


  25. Kido T, Schubert S, Schmidtke J, Chris Lau YF. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. 2011. PMID: 21621739


  26. Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. 2011. PMID: 21204751


  27. Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. 2010. PMID: 24710046


  28. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. 2009. PMID: 20028690


  29. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. The Journal of biological chemistry 2009. PMID: 19850934


  30. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. 2009. PMID: 19661285


  31. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. Developmental staging of male murine embryonic gonad by SAGE analysis. 2009. PMID: 19376482


  32. Lau YF, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. 2009. PMID: 19376480


  33. Lau YF, Li Y, Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. 2009. PMID: 19306348


  34. Dell'Orco D. Fast predictions of thermodynamics and kinetics of protein-protein recognition from structures: from molecular design to systems biology. Molecular bioSystems 2009. PMID: 19396368


  35. Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. 2008. PMID: 18808526


  36. Kido T, Lau YF. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. 2008. PMID: 18649364


  37. Li Y, Lau YF. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. 2008. PMID: 18591933


  38. Oh HJ, Kido T, Lau YF. PIAS1 interacts with and represses SOX9 transactivation activity. 2007. PMID: 17440973


  39. de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. JKT-1 is not a human seminoma cell line. 2007. PMID: 17705808


  40. Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. 2007. PMID: 17547684


  41. LAU YFC
    CHAN WY. Y Chromosome and Male Germ Cell Biology in Health and Diseases 2007. PMID:


  42. Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. 2007. PMID: 17521702


  43. Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. 2007. PMID: 17349529


  44. Kido T, Lau YF. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochemical and biophysical research communications 2006. PMID: 16996029


  45. Li Y, Oh HJ, Lau YF. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. 2006. PMID: 16904257


  46. Oram SW, Liu XX, Lee TL, Chan WY, Lau YF. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC cancer 2006. PMID: 16762081


  47. Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY. Structural characterization and expression studies of Dby and its homologs in the mouse. Journal of andrology 2006. PMID: 16728723


  48. Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. 2006. PMID: 16456896


  49. Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW. Germ cell lineage differentiation in non-seminomatous germ cell tumours. 2006. PMID: 16273510


  50. Oh HJ, Lau YF. KRAB: a partner for SRY action on chromatin. 2006. PMID: 16414182


  51. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. 2006. PMID: 16360422


  52. Kido T, Lau YF. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. 2005. PMID: 16035036


  53. Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Developmental dynamics : an official publication of the American Association of Anatomists 2005. PMID: 15789443


  54. Ganapathy K. Telemedicine in neurology. Neurology India 2005. PMID: 16010075


  55. Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. 2005. PMID: 15937962


  56. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. 2005. PMID: 15948118


  57. Oh HJ, Li Y, Lau YF. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. 2004. PMID: 15469996


  58. Lau YF, Lau HW, Kömüves LG. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. 2003. PMID: 14684991


  59. Li Y, Yue L, Taketo T, Lau YF. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. 2003. PMID: 14684989


  60. Liu WS, Nordqvist K, Lau YF, Fredga K. Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. 2001. PMID: 11748603


  61. Xian M, Zhang J, Lau YF. Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. 2001. PMID: 11748612


  62. Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. 2001. PMID: 11304517


  63. Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. 2000. PMID: 11013122


  64. Lau YF, Zhang J. Expression analysis of thirty one Y chromosome genes in human prostate cancer. 2000. PMID: 10747295


  65. Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF. The green fluorescent protein is an efficient biological marker for cardiac myocytes. 1999. PMID: 10640443


  66. Zhang J, Coward P, Xian M, Lau YF. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. 1999. PMID: 10410901


  67. Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. 1999. PMID: 10090875


  68. Diatchenko L, Lukyanov S, Lau YF, Siebert PD. Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes. 1999. PMID: 10349654


  69. Lau YF, Zhang J. Sry interactive proteins: implication for the mechanisms of sex determination. 1998. PMID: 9678346


  70. Shimamura R, Fraizer GC, Trapman J, Saunders GF. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. 1997. PMID: 9815658


  71. Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL. Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia. American journal of medical genetics 1997. PMID: 9128931


  72. Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA. Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. 1997. PMID: 9533010


  73. Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8650213


  74. Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF. Report of the Second International Workshop on Y Chromosome Mapping 1995. 1996. PMID: 8646888


  75. Dubin RA, Coward P, Lau YF, Ostrer H. Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes. 1995. PMID: 8614401


  76. Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. 1994. PMID: 8012385


  77. Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C. Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994. 1994. PMID: 7924456


  78. Boissonneault G, Lau YF. A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. 1993. PMID: 8321234


  79. Su H, Lau YF. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. 1993. PMID: 8434602


  80. Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF. Molecular isolation and characterization of an expressed gene from the human Y chromosome. 1992. PMID: 1284595


  81. Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. 1992. PMID: 1449792


  82. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. 1992. PMID: 1522559


  83. Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF. The musculus-type Y chromosome of the laboratory mouse is of Asian origin. 1992. PMID: 1352158


  84. Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. 1992. PMID: 1349859


  85. . American Academy of Pediatrics Committee on Drugs: Prescription drug advertising direct to the consumer. Pediatrics 1991. PMID: 2057258


  86. Liu MS, Chan KM, Lau YF, Lee CY. Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. 1990. PMID: 2331378


  87. Leung WY, Lindgren V, Lau YF, Yang-Feng YL. Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes. 1990. PMID: 2265557


  88. Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. 1990. PMID: 2393579


  89. Nagamine CM, Chan K, Hake LE, Lau YF. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. 1990. PMID: 1968414


  90. Lau YF, Chan KM. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. 1989. PMID: 2511751


  91. Lau YF, Chan KM, Sparkes R. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2813404


  92. Nagamine CM, Chan K, Lau YF. A PCR artifact: generation of heteroduplexes. 1989. PMID: 2631699


  93. Poole SJ, Law ML, Kao FT, Lau YF. Isolation and chromosomal localization of the human En-2 gene. 1989. PMID: 2565873


  94. Nagamine CM, Chan KM, Kozak CA, Lau YF. Chromosome mapping and expression of a putative testis-determining gene in mouse. 1989. PMID: 2563174


  95. Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N. The anonymous PAS45 probe detects RFLPs in 13q31. 1989. PMID: 2569289


  96. Kao FT, Wu KC, Law ML, Hartz JA, Lau YF. Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. 1988. PMID: 3175768


  97. LAU YF. Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems 1988. PMID:


  98. Kim YK, Wells S, Lau YF, Lee AS. Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3413063


  99. Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF. Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. 1988. PMID: 3231129


  100. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. The Journal of clinical investigation 1987. PMID: 3479442


  101. Boer PH, Adra CN, Lau YF, McBurney MW. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. 1987. PMID: 2823118


  102. Wu KC, Chan K, Lee CY, Lau YF. Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochemical and biophysical research communications 1987. PMID: 3619944


  103. Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. 1987. PMID: 2828182


  104. Lau YF, Chan KM, Kan YW, Goldberg E. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. 1987. PMID: 3455075


  105. Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. The Journal of biological chemistry 1986. PMID: 3733697


  106. Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. Cloning and expression of the human apolipoprotein E gene. 1986. PMID: 3014273


  107. Choo KH, Filby G, Greco S, Lau YF, Kan YW. Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene. 1986. PMID: 3468045


  108. Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW. Flow-sorting analysis of normal and abnormal human genomes. 1986. PMID: 3472713


  109. Lau YF, Ying KL, Donnell GN. Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. 1985. PMID: 2982722


  110. Lau YF, Schonberg S. A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. 1984. PMID: 6517059


  111. Lau YF, Lin CC, Kan YW. Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells. 1984. PMID: 6493227


  112. Lau YF, Huang JC, Dozy AM, Kan YW. A rapid screening test for antenatal sex determination. Lancet (London, England) 1984. PMID: 6140342


  113. Lau YF, Kan YW. Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6320187


  114. Lau YF, Kan YW. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proceedings of the National Academy of Sciences of the United States of America 1983. PMID: 6310566


  115. Lau YF, Lin CC, Kan YW. Amplification of the human alpha-globin gene enhances its expression. 1983. PMID: 6679967


  116. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units. 1981. PMID: 7028418


  117. Hubbell HR, Lau YF, Brown RL, Hsu TC. Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. 1980. PMID: 6159216


  118. Arrighi FE, Lau YF, Spallone A. Nucleolar activity in differentiated cells after stimulation. 1980. PMID: 6156056


  119. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes. 1980. PMID: 6156800


  120. Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE. Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings. 1979. PMID: 85597


  121. Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC. Combination of silver and fluorescent staining for metaphase chromosomes. 1978. PMID: 74950


  122. Lau YF, Brown RL, Arrighi FE. Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. 1977. PMID: 923665


  123. Lau YF, Arrighi FE, Chuang CR. Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns. 1977. PMID: 408102


  124. Lau YF, Hsu TC. Variable modes of Robertsonian fusions. 1977. PMID: 74307


  125. Lau YF, Hittelman WN, Arrighi FE. Sister chromatid differential staining pattern in prematurely condensed chromosomes. 1976. PMID: 954984


  126. Lau YF, Arrighi FE. Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity. 1976. PMID: 820523


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