Chris Lau, PhD
Education
Websites
Publications
Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Doerr HG, Woelfle J, Heidemann PH, Lau YC, Strowitzki T. Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§. Systems biology in reproductive medicine 2022. PMID: 35481403
Lau YC. The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience. Abdominal radiology (New York) 2021. PMID: 34906230
Lau YC. Y chromosome in health and diseases. 2020. PMID: 32817785
Kido T, Tabatabai ZL, Chen X, Lau YC. Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. 2020. PMID: 32473614
Lau YC, Li Y, Kido T. Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis. 2018. PMID: 29974883
Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T. Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY. 2019. PMID: 30753444
Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. 2019. PMID: 30863497
Kido T, Sun Z, Lau YC. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Scientific Reports 2017. PMID: 28646221
Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. 2017. PMID: 28169398
Kido T, Lau YC. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. 2016. PMID: 27771326
Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. 2015. PMID: 26036629
Kido T, Lau YF. Roles of the Y chromosome genes in human cancers. 2015. PMID: 25814157
Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. 2014. PMID: 25267720
Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. 2014. PMID: 25088423
Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. 2014. PMID: 25017435
Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochemical and biophysical research communications 2014. PMID: 24583132
Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. 2014. PMID: 24528896
Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. 2013. PMID: 23975793
Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. 2012. PMID: 22144232
Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PloS one 2011. PMID: 21829568
Kido T, Schubert S, Schmidtke J, Chris Lau YF. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. 2011. PMID: 21621739
Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. 2011. PMID: 21204751
Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. 2010. PMID: 24710046
Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. 2009. PMID: 20028690
Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. The Journal of biological chemistry 2009. PMID: 19850934
Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. 2009. PMID: 19661285
Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. Developmental staging of male murine embryonic gonad by SAGE analysis. 2009. PMID: 19376482
Lau YF, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. 2009. PMID: 19376480
Lau YF, Li Y, Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. 2009. PMID: 19306348
Dell'Orco D. Fast predictions of thermodynamics and kinetics of protein-protein recognition from structures: from molecular design to systems biology. Molecular bioSystems 2009. PMID: 19396368
Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. 2008. PMID: 18808526
Kido T, Lau YF. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. 2008. PMID: 18649364
Li Y, Lau YF. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. 2008. PMID: 18591933
Oh HJ, Kido T, Lau YF. PIAS1 interacts with and represses SOX9 transactivation activity. 2007. PMID: 17440973
de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. JKT-1 is not a human seminoma cell line. 2007. PMID: 17705808
Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. 2007. PMID: 17547684
LAU YFC
CHAN WY. Y Chromosome and Male Germ Cell Biology in Health and Diseases 2007. PMID:Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. 2007. PMID: 17521702
Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. 2007. PMID: 17349529
Kido T, Lau YF. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochemical and biophysical research communications 2006. PMID: 16996029
Li Y, Oh HJ, Lau YF. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. 2006. PMID: 16904257
Oram SW, Liu XX, Lee TL, Chan WY, Lau YF. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC cancer 2006. PMID: 16762081
Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY. Structural characterization and expression studies of Dby and its homologs in the mouse. Journal of andrology 2006. PMID: 16728723
Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. 2006. PMID: 16456896
Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW. Germ cell lineage differentiation in non-seminomatous germ cell tumours. 2006. PMID: 16273510
Oh HJ, Lau YF. KRAB: a partner for SRY action on chromatin. 2006. PMID: 16414182
Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. 2006. PMID: 16360422
Kido T, Lau YF. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. 2005. PMID: 16035036
Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Developmental dynamics : an official publication of the American Association of Anatomists 2005. PMID: 15789443
Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. 2005. PMID: 15937962
Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. 2005. PMID: 15948118
Oh HJ, Li Y, Lau YF. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. 2004. PMID: 15469996
Lau YF, Lau HW, Kömüves LG. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. 2003. PMID: 14684991
Li Y, Yue L, Taketo T, Lau YF. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. 2003. PMID: 14684989
Liu WS, Nordqvist K, Lau YF, Fredga K. Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. 2001. PMID: 11748603
Xian M, Zhang J, Lau YF. Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. 2001. PMID: 11748612
Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. 2001. PMID: 11304517
Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. 2000. PMID: 11013122
Lau YF, Zhang J. Expression analysis of thirty one Y chromosome genes in human prostate cancer. 2000. PMID: 10747295
Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF. The green fluorescent protein is an efficient biological marker for cardiac myocytes. 1999. PMID: 10640443
Zhang J, Coward P, Xian M, Lau YF. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. 1999. PMID: 10410901
Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. 1999. PMID: 10090875
Diatchenko L, Lukyanov S, Lau YF, Siebert PD. Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes. 1999. PMID: 10349654
Lau YF, Zhang J. Sry interactive proteins: implication for the mechanisms of sex determination. 1998. PMID: 9678346
Shimamura R, Fraizer GC, Trapman J, Saunders GF. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. 1997. PMID: 9815658
Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL. Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia. American journal of medical genetics 1997. PMID: 9128931
Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA. Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. 1997. PMID: 9533010
Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8650213
Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF. Report of the Second International Workshop on Y Chromosome Mapping 1995. 1996. PMID: 8646888
Dubin RA, Coward P, Lau YF, Ostrer H. Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes. 1995. PMID: 8614401
Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. 1994. PMID: 8012385
Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C. Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994. 1994. PMID: 7924456
Boissonneault G, Lau YF. A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. 1993. PMID: 8321234
Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF. Molecular isolation and characterization of an expressed gene from the human Y chromosome. 1992. PMID: 1284595
Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. 1992. PMID: 1449792
Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. 1992. PMID: 1522559
Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF. The musculus-type Y chromosome of the laboratory mouse is of Asian origin. 1992. PMID: 1352158
Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. 1992. PMID: 1349859
. American Academy of Pediatrics Committee on Drugs: Prescription drug advertising direct to the consumer. Pediatrics 1991. PMID: 2057258
Liu MS, Chan KM, Lau YF, Lee CY. Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. 1990. PMID: 2331378
Leung WY, Lindgren V, Lau YF, Yang-Feng YL. Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes. 1990. PMID: 2265557
Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. 1990. PMID: 2393579
Nagamine CM, Chan K, Hake LE, Lau YF. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. 1990. PMID: 1968414
Lau YF, Chan KM. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. 1989. PMID: 2511751
Lau YF, Chan KM, Sparkes R. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2813404
Nagamine CM, Chan K, Lau YF. A PCR artifact: generation of heteroduplexes. 1989. PMID: 2631699
Poole SJ, Law ML, Kao FT, Lau YF. Isolation and chromosomal localization of the human En-2 gene. 1989. PMID: 2565873
Nagamine CM, Chan KM, Kozak CA, Lau YF. Chromosome mapping and expression of a putative testis-determining gene in mouse. 1989. PMID: 2563174
Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N. The anonymous PAS45 probe detects RFLPs in 13q31. 1989. PMID: 2569289
Kao FT, Wu KC, Law ML, Hartz JA, Lau YF. Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. 1988. PMID: 3175768
Kim YK, Wells S, Lau YF, Lee AS. Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3413063
Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF. Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. 1988. PMID: 3231129
Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. The Journal of clinical investigation 1987. PMID: 3479442
Boer PH, Adra CN, Lau YF, McBurney MW. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. 1987. PMID: 2823118
Wu KC, Chan K, Lee CY, Lau YF. Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochemical and biophysical research communications 1987. PMID: 3619944
Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. 1987. PMID: 2828182
Lau YF, Chan KM, Kan YW, Goldberg E. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. 1987. PMID: 3455075
Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. The Journal of biological chemistry 1986. PMID: 3733697
Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. Cloning and expression of the human apolipoprotein E gene. 1986. PMID: 3014273
Choo KH, Filby G, Greco S, Lau YF, Kan YW. Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene. 1986. PMID: 3468045
Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW. Flow-sorting analysis of normal and abnormal human genomes. 1986. PMID: 3472713
Lau YF, Ying KL, Donnell GN. Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. 1985. PMID: 2982722
Lau YF, Schonberg S. A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. 1984. PMID: 6517059
Lau YF, Lin CC, Kan YW. Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells. 1984. PMID: 6493227
Lau YF, Huang JC, Dozy AM, Kan YW. A rapid screening test for antenatal sex determination. Lancet (London, England) 1984. PMID: 6140342
Lau YF, Kan YW. Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6320187
Lau YF, Kan YW. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proceedings of the National Academy of Sciences of the United States of America 1983. PMID: 6310566
Lau YF, Lin CC, Kan YW. Amplification of the human alpha-globin gene enhances its expression. 1983. PMID: 6679967
Lau YF, Arrighi FE. Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units. 1981. PMID: 7028418
Hubbell HR, Lau YF, Brown RL, Hsu TC. Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. 1980. PMID: 6159216
Arrighi FE, Lau YF, Spallone A. Nucleolar activity in differentiated cells after stimulation. 1980. PMID: 6156056
Lau YF, Arrighi FE. Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes. 1980. PMID: 6156800
Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE. Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings. 1979. PMID: 85597
Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC. Combination of silver and fluorescent staining for metaphase chromosomes. 1978. PMID: 74950
Lau YF, Brown RL, Arrighi FE. Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. 1977. PMID: 923665
Lau YF, Arrighi FE, Chuang CR. Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns. 1977. PMID: 408102
Lau YF, Hsu TC. Variable modes of Robertsonian fusions. 1977. PMID: 74307
Lau YF, Hittelman WN, Arrighi FE. Sister chromatid differential staining pattern in prematurely condensed chromosomes. 1976. PMID: 954984
Lau YF, Arrighi FE. Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity. 1976. PMID: 820523